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How Integrated Bypass Technology Provides Pressure Control for Biopharma

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In pharmaceutical and biopharmaceutical manufacturing, there is zero margin for error when it comes to process integrity and operator safety. Among the many variables that must be tightly controlled, pressure ranks high on the list. Overpressure or vacuum conditions can compromise not only equipment, but also batch sterility, production timelines, and ultimately, patient safety

As pressure control requirements evolve alongside the adoption of single-use systems, a new generation of integrated solutions is gaining traction – offering embedded safety without sacrificing speed, sterility, or scalability. One example of this shift is Xylem’s Jabsco PureFlo 21 Single Use pump.

Designed with both performance and simplicity in mind, the pump incorporates an integrated, adjustable bypass that automatically recirculates fluid within the pump head when pressure thresholds are exceeded. This allows the system to recover without disruption, eliminating the need for external relief devices and enabling seamless operation under fluctuating conditions.

Pressure protection is more than just a regulatory checkbox, it’s an opportunity to engineer smarter, cleaner, and more sustainable systems. The PureFlo 21 Single Use delivers on that promise by combining embedded safety, system simplicity, and environmental stewardship in one innovative design.

 

Click here to Download the whitepaper

Company: Xylem


Xylem is a global water technology provider helping customers solve the world's toughest water and fluid challenges across utility, industrial, commercial and residential markets.

Over the last 100+ years, our unique combination of innovative products and services, proven expertise and unmatched customer support have  dramatically improve the way water and wastewater are used, managed, conserved, re-used and returned to nature.

Central to that mission are three of the world's most trusted names in fluid handling – Jabsco, Flojet and Rule. As market leaders in controlled flow pumping technology, these brands bring the highest level of reliability, precision and control to a wide range of critical applications.

Backed by Xylem's global reach and deep engineering heritage, Jabsco, Flojet and Rule come with the technical expertise and custom engineering that manufacturers need to drive innovation, grow market share and meet the needs of end users.

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