Quanticate, a global data-focused clinical research organisation (CRO), has partnered with leading cancer research organisation, Cancer Research UK, to launch the DETERMINE study which will test a range of therapies specifically targeting key genetic changes in cancer cells.
The first of its kind in the UK, the DETERMINE study will enrol patients with rare cancers, and aim to find out whether existing licensed drugs could be used to treat their type of cancer.
Cohorts will be formed of patients who have an identifiable genetic alteration in their cancer that can be targeted by treatments already approved for use in other cancer types.
Quanticate has been working with Cancer Research UK’s Centre for Drug Development to ensure the statistical design of the study is optimised.
“The study will strive to improve the outcome for patients who may have run out of options during their cancer journey” commented David Underwood, CEO at Quanticate.
“Cancer Research UK has asked adults, young people and children who are suffering with a rare type of cancer to come forward with the possibility that there may be an existing approved drug that could benefit them. Furthermore, analysis from this study could also open up successful treatment options for other patients with similar cancer types who are not enrolled on the trial.”
“Quanticate is delighted to partner with Cancer Research UK for a program so close to home for many people and we are hopeful that the study will be successful in finding results that will improve the quality of life for many patients.”
Dr Nigel Blackburn, Director of Cancer Research UK’s Centre for Drug Development said of the project “We’re delighted to partner with Quanticate and welcome the valuable expertise they bring to this incredibly important trial which will allow potentially life-saving treatments to be opened up to people with rare cancers.”
The study will commence across the UK from September 2022. Approximately 15-20 treatment arms will open, each with initial trial cohorts with a target sample size of 30 evaluable patients.
Quanticate is one of the world’s largest global data-focused clinical research organisations (CROs) with a primary focus on data capture, statistical analysis, and clinical trial reporting.