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Thermo Fisher Scientific’s KingFisher Compact System Automates Sample Purification

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Sample purification is an important step in research workflows involving DNA, RNA and proteins. Consistent purification helps laboratories prepare samples for a range of research applications, making reliable and efficient preparation methods essential. The Thermo Scientific KingFisher Compact Purification System from Thermo Fisher Scientific automates DNA and RNA extraction, as well as protein purification, for one to 16 samples at a time.

The benchtop instrument has a compact design, measuring approximately 9 inches (23 cm) in each dimension. Its size allows it to fit on crowded laboratory benches and inside most biosafety cabinets, helping free up valuable bench space.

Magnetic Bead-Based Purification

The KingFisher Compact Purification System uses magnetic bead-based chemistry for sample preparation. Compatible purification solutions include Applied Biosystems MagMAX kits, Invitrogen Dynabeads and Thermo Scientific Pierce beads. These options support purification workflows involving different sample types.

The instrument automates three key stages of the purification process: binding, washing and elution. It features preloaded and verified protocols designed to help consistently achieve high purification quality, purity and yield. The system also provides the option to create or customise protocols to accommodate specific workflow requirements.

Compatible kits include the MagMAX mirVana Total RNA Isolation Kit (A27828), MagMAX DNA Multi-Sample Ultra 2.0 Kit (A36570), MagMAX Prime Viral/Pathogen NA Isolation Kit (A58145), MagMAX HMW DNA Kit and Booster (A36626), and MagMAX Pure Bind Beads (A58521).

This combination of automated processing and protocol customisation allows the instrument to be used for both common and challenging sample types. Researchers can select the appropriate purification chemistry and workflow according to their sample preparation needs.

Applications Across Research Areas

The KingFisher Compact Purification System is intended for everyday research applications across oncology, immunology, drug discovery and infectious disease. Its capacity to purify DNA, RNA and proteins supports laboratories working with different analytes and research requirements.

The system processes between one and 16 samples at a time, making it suitable for workflows within this stated sample capacity. Its compact benchtop format also allows laboratories to position the instrument in different working environments, including most biosafety cabinets.

Request a Demonstration or Quote

The Thermo Scientific KingFisher Compact Purification System combines magnetic bead-based chemistry with automated binding, washing and elution steps for DNA, RNA and protein purification. Researchers interested in understanding how the system can support their sample purification workflows can request a quote or demo from Thermo Fisher Scientific.

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