Close

AstraZeneca (AZ) and Eli Lilly have started AMARANTH, a phase II/III study investigating a potential treatment for early Alzheimer’s disease.

Note* - All images used are for editorial and illustrative purposes only and may not originate from the original news provider or associated company.

Subscribe

- Never miss a story with notifications

- Gain full access to our premium content

- Browse free from any location or device.

Media Packs

Expand Your Reach With Our Customized Solutions Empowering Your Campaigns To Maximize Your Reach & Drive Real Results!

– Access the Media Pack Now

– Book a Conference Call

– Leave Message for Us to Get Back

Related stories

Top Books Every Aspiring Pharmacist Should Read

Foundations That Shape the Profession Every pharmacist begins with a...

LOTTE BIOLOGICS Enters Contract Manufacturing Collaboration

LOTTE BIOLOGICS, on September 1, 2025, announced that it...

Cook Medical Says Extra Tariff to Be Passed to US Customers

According to medical device firm Cook Medical, the costs...

FDA Aims to Decrease Animal Testing as Tech Gathers Pace

Drug developers are raising the adoption of AI technologies...

The trial will examine oral beta secretase cleaving enzyme (BACE) inhibitor AZD3293, also known as LY3314814, which reduced levels of amyloid-beta in the cerebro-spinal fluid of Alzheimer’s patients and healthy volunteers in phase I studies.

Other potential Alzheimer’s disease treatments have fallen by the wayside in recent years, including Lilly’s gamma secretase inhibitor semagacestat, Bristol-Myers Squibb’s avagacestat, as well as Pfizer and Johnson & Johnson’s amyloid-targeting antibody bapineuzumab.

Merck is also working on its own BACE inhibitor, with its MK-8931 currently in phase II/III for mild-to-moderate forms of the disease.

The hope is that the BACE route could end the long run of failures experienced by the industry – which, in Lilly’s case, has spanned 25 years of investigation into potential Alzheimer’s candidates.

The progression of Alzheimer’s disease is characterised by the accumulation of amyloid plaque in the brain. BACE is an enzyme associated with the development of beta-amyloid. Inhibiting BACE is expected to prevent the formation of amyloid plaque and eventually slow the progression of the disease.

Samantha Budd, vice president and head of Translational Science in AZ’s Neuroscience Innovative Medicines Unit explained: “We believe that BACE inhibitors have the potential to target one of the key drivers of this devastating disease. Together with Lilly, we have unique expertise that will allow us to evaluate the potential of AZD3293 as a treatment for Alzheimer’s patients.”

The first patient enrolment in AMARANTH comes less than three months since the two pharma giants announced their alliance to development and commercialise AZD3293/LY331481 and aims to enrol more than 1,500 patients in 15 countries.

Lilly will lead clinical development, working with researchers from AZ’s Neuroscience Innovative Medicines Unit, while AZ will be responsible for manufacturing. The companies will take joint responsibility for commercialisation and will share future costs and revenues equally.

 

Latest stories

Related stories

Top Books Every Aspiring Pharmacist Should Read

Foundations That Shape the Profession Every pharmacist begins with a...

LOTTE BIOLOGICS Enters Contract Manufacturing Collaboration

LOTTE BIOLOGICS, on September 1, 2025, announced that it...

Cook Medical Says Extra Tariff to Be Passed to US Customers

According to medical device firm Cook Medical, the costs...

FDA Aims to Decrease Animal Testing as Tech Gathers Pace

Drug developers are raising the adoption of AI technologies...

Subscribe

- Never miss a story with notifications

- Gain full access to our premium content

- Browse free from any location or device.

Media Packs

Expand Your Reach With Our Customized Solutions Empowering Your Campaigns To Maximize Your Reach & Drive Real Results!

– Access theMedia Pack Now

– Book a Conference Call

– Leave Message for Us to Get Back