Centivax partners with US NMRC to study Covid-19 antibody

Note* - All images used are for editorial and illustrative purposes only and may not originate from the original news provider or associated company.

Subscribe

- Never miss a story with notifications

- Gain full access to our premium content

- Browse free from any location or device.

Media Packs

Expand Your Reach With Our Customized Solutions Empowering Your Campaigns To Maximize Your Reach & Drive Real Results!

– Access the Media Pack Now

– Book a Conference Call

– Leave Message for Us to Get Back

Related stories

PDUFA Crucial for Biopharmaceutical Innovation in the US

The United States happens to lead the world when...

Fangzhou Inc. at PHARMCHINA Showcases AI-Powered Healthcare

The 4th Annual "Internet + Pharma" Service Innovation Conference,...

The Evolution of Self-Care: Where Vitauthority Fits in the Wellness Era

Over the past few decades, the concept of self-care...

Piramal Pharma Expands Lexington Sterile Injectables Plant

Piramal Pharma has started work on the expansion of...

Centivax has signed a strategic collaboration with the US Naval Medical Research Center (NMRC) to conduct Phase I clinical development of its SARS-CoV-2 antibody, Centi-B9.

Centi-B9 is designed as a broad-spectrum therapeutic and prophylactic for administration through injections. It is also expected to act as an adjunct to vaccines to ensure broad protection.

The antibody is engineered to neutralise the emergent Covid-19 mutated variants and showed broad-spectrum reactivity against 99.5% of all variants in the US.

It also demonstrated reactivity against more than 98% of Covid-19 variants seen worldwide which includes UK B.1.1.7, South African B.1.351, Brazilian P.1, New York B.1.526 and California B.1.429 strains.

Bioengineered for greater stability, reduced viscosity high concentration (250mg/ml) delivery, the antibody facilitates a prophylactic or therapeutic dose that can be administrated in a non-hospital setting via a single injection.

In addition, Centi-B9 was engineered using Xencor Xtend technology for improved safety and half-life.

Centivax CEO Dr David Gangemi said: “Our highly concentrated, thermostable, neutralising antibody fits the needs of the Navy, and DOD in general, in that it can be administered intramuscularly to warfighters in cramped quarters or austere environments to boost and extend protection already afforded by vaccination.

“Our antibody is highly effective against over 98% of the currently circulating variants and is a good fit for use in prolonged deployments when prophylaxis and/or post-exposure treatment is needed.”

As part of the collaboration, Centivax and NMRC will each provide a principal investigator for the clinical study.

NMRC will hold the Phase I clinical trial centre for intramuscular and subcutaneous administration of Centi-B9 and offer protocol development and medical management support.

Furthermore, the Henry Jackson Foundation is offering $4.2m non-dilutive funding for the trial.

The Phase I trial, which will validate Centi-B9’s safety and pharmacokinetics in healthy subjects, is anticipated to start next month.

These Phase I studies will facilitate a Phase II/III adaptive trial later this year.

The Phase II/III trial will analyse the antibody’s efficacy in various patient populations, such as hospitalised Covid-19 patients, pre-hospitalised individuals with the infection, post-exposure prophylaxis as well as pre-exposure prophylaxis.

Centivax intends to submit an application to obtain Emergency Use Authorization (EUA) during the interim analysis of the trial.

Latest stories

Related stories

PDUFA Crucial for Biopharmaceutical Innovation in the US

The United States happens to lead the world when...

Fangzhou Inc. at PHARMCHINA Showcases AI-Powered Healthcare

The 4th Annual "Internet + Pharma" Service Innovation Conference,...

The Evolution of Self-Care: Where Vitauthority Fits in the Wellness Era

Over the past few decades, the concept of self-care...

Piramal Pharma Expands Lexington Sterile Injectables Plant

Piramal Pharma has started work on the expansion of...

Subscribe

- Never miss a story with notifications

- Gain full access to our premium content

- Browse free from any location or device.

Media Packs

Expand Your Reach With Our Customized Solutions Empowering Your Campaigns To Maximize Your Reach & Drive Real Results!

– Access the Media Pack Now

– Book a Conference Call

– Leave Message for Us to Get Back