The largest completed study to date on treatments to reduce recurrence of blood clots in cancer patients, sponsored by LEO Pharma, has now been published in JAMA (The Journal of American Medical Association) JAMA. 2015;314(7):677-686.
The study showed that innohep® lowered the risk of recurrent venous thromboembolism (VTE) compared to treatment with warfarin in cancer patients with symptomatic venous thromboembolism. Although the primary endpoint was not met at the 5% level, this difference may be clinically relevant in the management of patients with cancer associated thrombosis (CAT). The study also showed that treatment with innohep® significantly reduced clinically relevant non-major bleeding compared to warfarin.
Blood clots are one of the leading causes of death in patients with cancer. Approximately 1 in 10 patients with cancer dies from a blood clot related event (1,2).
“Cancer patients with VTE have a substantial risk of developing new blood clots, and optimal treatment to avoid recurrence is vital. Advancing knowledge within this area is therefore a high priority for us at LEO Pharma. We hope that the results from the CATCH study (Comparison of Acute Treatments in Cancer Haemostasis) will help to further improve the management of blood clots in cancer patients” says Kim Kjoeller, Senior Vice President from LEO Pharma.
Despite clinical practice guidelines recommending the use of low-molecular-weight heparins (LMWH) like innohep®, warfarin remains a frequently used anticoagulant treatment worldwide for cancer patients with recurrent VTE(3). The CATCH study sponsored by LEO Pharma supports the previous findings and the clinical practice guidelines.
The CATCH study is a Phase III, multinational, concealed, randomised, active-controlled, open-label trial with blinded adjudication. 900 cancer patients from Europe, Africa, Asia, North America and South America were enrolled in the study. 449 patients were treated with tinzaparin (innohep®) and 451 were treated with warfarin over a period of 180 days. During the treatment period, 7.2% of the patients treated with innohep® experienced recurrent blood clots compared to 10.5% of the patients treated with warfarin.
Dr. Agnes Lee, MD, University of British Columbia and Vancouver Coastal Health in Canada and Principal Investigator of the CATCH study commented: “This global study reinforces clinical guidelines supporting the use of low-molecular-weight heparins instead of warfarin to prevent recurrent blood clots in these patients. Our results also offer the first look at other important issues in this high-risk population, including identification of biomarkers that may predict for higher risk of recurrent blood clots, quality of life and health care economics”. About LEO Pharma
About LEO Pharma
Founded in 1908, LEO Pharma is an independent, research-based pharmaceutical company. LEO Pharma develops, manufactures and markets pharmaceutical drugs to thrombotic and dermatologic patients in more than 100 countries globally. The company has its own sales force in 61 countries and employs around 4.800 people worldwide. LEO Pharma is headquartered in Denmark and is wholly owned by the LEO Foundation. For more information about LEO Pharma, please visit www.leo-pharma.com.